Efficacy of Pritelivir and Acyclovir in the Treatment of Herpes Simplex Virus Infections in a Mouse Model of Herpes Simplex Encephalitis

Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 hours after infection for 7 days with pritelivir or acyclovir. Both drug...

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Publicat a:Antiviral Res
Autors principals: Quenelle, Debra C., Birkmann, Alexander, Goldner, Thomas, Pfaff, Tamara, Zimmermann, Holger, Bonsmann, Susanne, Collins, Deborah J., Rice, Terri L., Prichard, Mark N.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743594/
https://ncbi.nlm.nih.gov/pubmed/29113740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.11.002
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