Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

Pharmacokinetic and pharmacodynamic models estimate the potency of antiviral agents but do not capture viral and immunologic factors that drive the natural dynamics of infection. We designed a mathematical model that synthesizes pharmacokinetics, pharmacodynamics and viral pathogenesis concepts to s...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Schiffer, Joshua T., Swan, David A., Magaret, Amalia, Corey, Lawrence, Wald, Anna, Ossig, Joachim, Ruebsamen-Schaeff, Helga, Stoelben, Susanne, Timmler, Burkhard, Zimmermann, Holger, Melhem, Murad R., Van Wart, Scott A., Rubino, Christopher M., Birkmann, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880060/
https://ncbi.nlm.nih.gov/pubmed/26843190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad6654
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