Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

9-R-[2-(Phosphonomethoxy)propyl]-adenine (tenofovir) is an acyclic nucleoside phosphonate with antiviral activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). Tenofovir is not orally bioavailable but becomes orally active against HIV-1 infection as the disoproxil...

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Detalhes bibliográficos
Main Authors: Painter, George R., Almond, Merrick R., Trost, Lawrence C., Lampert, Bernhard M., Neyts, Johan, De Clercq, Erik, Korba, Brent E., Aldern, Kathy A., Beadle, James R., Hostetler, Karl Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043283/
https://ncbi.nlm.nih.gov/pubmed/17646420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00460-07
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