Alkoxyalkyl Esters of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine Are Potent Inhibitors of the Replication of Wild-Type and Drug-Resistant Human Immunodeficiency Virus Type 1 In Vitro

(S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA], is an effective broad-spectrum antiviral against many DNA viruses but has been reported to be inactive against human immunodeficiency virus (HIV). We synthesized several alkoxyalkyl esters of (S)-HPMPA and now report that hexadecyloxyp...

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Auteurs principaux: Hostetler, Karl Y., Aldern, Kathy A., Wan, William B., Ciesla, Stephanie L., Beadle, James R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538655/
https://ncbi.nlm.nih.gov/pubmed/16870786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01223-05
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