Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

Por Myeku, Natura, Duff, Karen E.
Publicado no Trends Mol Med (2017)

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

Por Alldred, Melissa J., Duff, Karen E., Ginsberg, Stephen D.
Publicado em 2011

Mechanisms of Protein Seeding in Neurodegenerative Diseases

Por Walker, Lary C., Diamond, Marc I., Duff, Karen E., Hyman, Bradley T.
Publicado em 2013

Structure-activity relationship of cyanine tau aggregation inhibitors

Por Chang, Edward, Congdon, Erin E., Honson, Nicolette S., Duff, Karen E., Kuret, Jeff
Publicado em 2009

Noninvasive and Transient Blood-Brain Barrier Opening in the Hippocampus of Alzheimer's Double Transgenic Mice Using Focused Ultrasound

Por Choi, James J., Wang, Shougang, Brown, Truman R., Small, Scott A., Duff, Karen E. K., Konofagou, Elisa E.
Publicado em 2008

Inhibition of Tau Polymerization with a Cyanine Dye in Two Distinct Model Systems

Por Congdon, Erin E., Figueroa, Yvette H., Wang, Lili, Toneva, Galina, Chang, Edward, Kuret, Jeff, Conrad, Christopher, Duff, Karen E.
Publicado em 2009

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

Por Myeku, Natura, Clelland, Catherine L, Emrani, Sheina, Kukushkin, Nikolay V, Yu, Wai Haung, Goldberg, Alfred L, Duff, Karen E
Publicado no Nat Med (2015)

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

Por Yu, Wai Haung, Dorado, Beatriz, Figueroa, Helen Yvette, Wang, Lili, Planel, Emmanuel, Cookson, Mark R., Clark, Lorraine N., Duff, Karen E.
Publicado em 2009

Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia

Por Planel, Emmanuel, Bretteville, Alexis, Liu, Li, Virag, Laszlo, Du, Angela L., Yu, Wai Haung, Dickson, Dennis W., Whittington, Robert A., Duff, Karen E.
Publicado em 2009

Vitamin D Insufficiency and Schizophrenia Risk: Evaluation of Hyperprolinemia as a Mediator of Association

Por Clelland, James D., Read, Laura L., Drouet, Valérie, Kaon, Angela, Kelly, Alexandra, Duff, Karen E., Nadrich, Robert H, Rajparia, Amit, Clelland, Catherine L.
Publicado em 2014

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease

Por Fu, Hongjun, Rodriguez, Gustavo A., Herman, Mathieu, Emrani, Sheina, Nahmani, Eden, Barrett, Geoffrey, Figueroa, Helen Y., Goldberg, Eliana, Hussaini, S. Abid, Duff, Karen E.
Publicado no Neuron (2017)

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer’s disease

Por Khan, Usman A, Liu, Li, Provenzano, Frank A, Berman, Diego E, Profaci, Caterina P, Sloan, Richard, Mayeux, Richard, Duff, Karen E, Small, Scott A
Publicado em 2013

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

Por Chan, Robin B., Oliveira, Tiago G., Cortes, Etty P., Honig, Lawrence S., Duff, Karen E., Small, Scott A., Wenk, Markus R., Shui, Guanghou, Di Paolo, Gilbert
Publicado em 2012

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Age...

Por Fu, Hongjun, Hussaini, S. Abid, Wegmann, Susanne, Profaci, Caterina, Daniels, Jacob D., Herman, Mathieu, Emrani, Sheina, Figueroa, Helen Y., Hyman, Bradley T., Davies, Peter, Duff, Karen E.
Publicado no PLoS One (2016)

Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury

Por Loane, David J., Washington, Patricia M., Vardanian, Lilit, Pocivavsek, Ana, Hoe, Hyang-Sook, Duff, Karen E., Cernak, Ibolja, Rebeck, G. William, Faden, Alan I., Burns, Mark P.
Publicado em 2011

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

Por Congdon, Erin E., Wu, Jessica W., Myeku, Natura, Figueroa, Yvette H., Herman, Mathieu, Marinec, Paul S., Gestwicki, Jason E., Dickey, Chad A., Yu, W. Haung, Duff, Karen E.
Publicado em 2012

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Por Nuriel, Tal, Peng, Katherine Y., Ashok, Archana, Dillman, Allissa A., Figueroa, Helen Y., Apuzzo, Justin, Ambat, Jayanth, Levy, Efrat, Cookson, Mark R., Mathews, Paul M., Duff, Karen E.
Publicado no Front Neurosci (2017)

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

Por Wu, Jessica W., Herman, Mathieu, Liu, Li, Simoes, Sabrina, Acker, Christopher M., Figueroa, Helen, Steinberg, Joshua I., Margittai, Martin, Kayed, Rakez, Zurzolo, Chiara, Di Paolo, Gilbert, Duff, Karen E.
Publicado em 2013

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

Por Oliveira, Tiago Gil, Chan, Robin B., Tian, Huasong, Laredo, Mikael, Shui, Guanghou, Staniszewski, Agnieszka, Zhang, Hong, Wang, Lili, Kim, Tae-Wan, Duff, Karen E., Wenk, Markus R., Arancio, Ottavio, Di Paolo, Gilbert
Publicado em 2010

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

Por Planel, Emmanuel, Krishnamurthy, Pavan, Miyasaka, Tomohiro, Liu, Li, Herman, Mathieu, Kumar, Asok, Bretteville, Alexis, Figueroa, Helen Y., Haung Yu, Wai, Whittington, Robert A., Davies, Peter, Takashima, Akihiko, Nixon, Ralph A., Duff, Karen E.
Publicado em 2008