Inhibition of Tau Polymerization with a Cyanine Dye in Two Distinct Model Systems

In a host of neurodegenerative diseases Tau, a microtubule-associated protein, aggregates into insoluble lesions within neurons. Previous studies have utilized cyanine dyes as Tau aggregation inhibitors in vitro. Herein we utilize cyanine dye 3,3′-diethyl-9-methyl-thiacarbocyanine iodide (C11) to mo...

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Detalhes bibliográficos
Main Authors: Congdon, Erin E., Figueroa, Yvette H., Wang, Lili, Toneva, Galina, Chang, Edward, Kuret, Jeff, Conrad, Christopher, Duff, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742848/
https://ncbi.nlm.nih.gov/pubmed/19478088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016089
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