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Structural Determinants of Tau Aggregation Inhibitor Potency

Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identificatio...

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Detalhes bibliográficos
Main Authors: Schafer, Kelsey N., Cisek, Katryna, Huseby, Carol J., Chang, Edward, Kuret, Jeff
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820892/
https://ncbi.nlm.nih.gov/pubmed/24072703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503474
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