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Structure-activity relationship of cyanine tau aggregation inhibitors
A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents. One potent member of the series, 3,3’-di...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745078/ https://ncbi.nlm.nih.gov/pubmed/19432420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900116d |
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