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Structure-activity relationship of cyanine tau aggregation inhibitors

A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents. One potent member of the series, 3,3’-di...

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Detalhes bibliográficos
Main Authors: Chang, Edward, Congdon, Erin E., Honson, Nicolette S., Duff, Karen E., Kuret, Jeff
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745078/
https://ncbi.nlm.nih.gov/pubmed/19432420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900116d
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