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Nucleation-dependent Tau Filament Formation: THE IMPORTANCE OF DIMERIZATION AND AN ESTIMATION OF ELEMENTARY RATE CONSTANTS

Filamentous inclusions composed of the microtubule-associated protein tau are found in Alzheimer disease and other tauopathic neurodegenerative diseases, but the mechanisms underlying their formation from full-length protein monomer under physiological conditions are unclear. To address this issue,...

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Bibliografische gegevens
Hoofdauteurs: Congdon, Erin E., Kim, Sohee, Bonchak, Jonathan, Songrug, Tanakorn, Matzavinos, Anastasios, Kuret, Jeff
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376241/
https://ncbi.nlm.nih.gov/pubmed/18359772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800247200
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