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Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps
Mutations in the MAPT gene encoding tau protein lead to neurofibrillary lesion formation, neurodegeneration, and cognitive decline associated with frontotemporal lobar degeneration. While some pathogenic mutations affect MAPT introns, resulting in abnormal splicing patterns, the majority occur in th...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596975/ https://ncbi.nlm.nih.gov/pubmed/18803694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05692.x |
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