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Modulation and detection of tau aggregation with small-molecule ligands

Recent results from high-throughput and other screening approaches reveal that small molecules can directly interact with recombinant full-length tau monomers and fibrillar tau aggregates in three distinct modes. First, in the high concentration regime (>10 micromolar), certain anionic molecules...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chang, Edward, Honson, Nicolette S., Bandyopadhyay, Bhaswati, Funk, Kristen E., Jensen, Jordan R., Kim, Sohee, Naphade, Swati, Kuret, Jeff
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725300/
https://ncbi.nlm.nih.gov/pubmed/19874263
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