Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury

Traumatic brain injury (TBI) increases brain beta-amyloid (Aβ) in humans and animals. Although the role of Aβ in the injury cascade is unknown, multiple preclinical studies have demonstrated a correlation between reduced Aβ and improved outcome. Therefore, therapeutic strategies that enhance Aβ clea...

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Autors principals: Loane, David J., Washington, Patricia M., Vardanian, Lilit, Pocivavsek, Ana, Hoe, Hyang-Sook, Duff, Karen E., Cernak, Ibolja, Rebeck, G. William, Faden, Alan I., Burns, Mark P.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2011
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037807/
https://ncbi.nlm.nih.gov/pubmed/21175399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2010.1595
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