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β-Amyloid(1–42) Gene Transfer Model Exhibits Intraneuronal Amyloid, Gliosis, Tau Phosphorylation, and Neuronal Loss

Alzheimer disease is characterized by extracellular β-amyloid (Aβ) plaques and intracellular inclusions containing neurofibrillary tangles of phospho-Tau and intraneuronal Aβ associated with neuronal cell death. We generated a novel gene transfer animal model using lentiviral Aβ(1–42) that resulted...

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Hlavní autoři: Rebeck, G. William, Hoe, Hyang-Sook, Moussa, Charbel E.-H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844192/
https://ncbi.nlm.nih.gov/pubmed/20071340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083915
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