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Human APOE genotype affects intraneuronal Aβ(1–42) accumulation in a lentiviral gene transfer model
Intraneuronal accumulation of β-amyloid (Aβ)(42) is one of the earliest pathological events in humans and in animal models of Alzheimer's disease (AD). Apolipoprotein E 4 (APOE4) is the major identified genetic risk factor for late-onset AD, with Aβ deposition beginning earlier in apoE4-positiv...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919009/ https://ncbi.nlm.nih.gov/pubmed/24154541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt525 |
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