Human APOE genotype affects intraneuronal Aβ(1–42) accumulation in a lentiviral gene transfer model

Intraneuronal accumulation of β-amyloid (Aβ)(42) is one of the earliest pathological events in humans and in animal models of Alzheimer's disease (AD). Apolipoprotein E 4 (APOE4) is the major identified genetic risk factor for late-onset AD, with Aβ deposition beginning earlier in apoE4-positiv...

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Huvudupphovsmän: Zhao, Wenjuan, Dumanis, Sonya B., Tamboli, Irfan Y., Rodriguez, Gustavo A., Jo LaDu, Mary, Moussa, Charbel E.H., William Rebeck, G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919009/
https://ncbi.nlm.nih.gov/pubmed/24154541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt525
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