Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

Amyloid-β (Aβ) peptides, found in Alzheimer’s disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either β- or γ-secretase, enzymes required for production of Aβ from amyloid precursor protein (APP), can ameliorate motor and cog...

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Autori principali: Loane, David J, Pocivavsek, Ana, Moussa, Charbel E-H, Thompson, Rachel, Matsuoka, Yasuji, Faden, Alan I, Rebeck, G William, Burns, Mark P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844765/
https://ncbi.nlm.nih.gov/pubmed/19287391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1940
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