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Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
Amyloid-β (Aβ) peptides, found in Alzheimer’s disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either β- or γ-secretase, enzymes required for production of Aβ from amyloid precursor protein (APP), can ameliorate motor and cog...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844765/ https://ncbi.nlm.nih.gov/pubmed/19287391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1940 |
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