Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

Amyloid-β (Aβ) peptides, found in Alzheimer’s disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either β- or γ-secretase, enzymes required for production of Aβ from amyloid precursor protein (APP), can ameliorate motor and cog...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Loane, David J, Pocivavsek, Ana, Moussa, Charbel E-H, Thompson, Rachel, Matsuoka, Yasuji, Faden, Alan I, Rebeck, G William, Burns, Mark P
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844765/
https://ncbi.nlm.nih.gov/pubmed/19287391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1940
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares