The Saccharomyces SUN gene, UTH1, is Involved in Cell Wall Biogenesis

Por Ritch, James J., Davidson, Shawn M., Sheehan, Jared J., Austriaco O.P., Nicanor
Publicado em 2009

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Por Papagiannakopoulos, Thales, Bauer, Matthew, Davidson, Shawn, Heimann, Megan, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan, Heiden, Matthew Vander, Jacks, Tyler
Publicado no Cell Metab (2016)

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

Por Mattaini, Katherine R, Brignole, Edward J, Kini, Mitali, Davidson, Shawn M, Fiske, Brian P, Drennan, Catherine L, Vander Heiden, Matthew G
Publicado no Cancer Metab (2015)

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

Por Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Publicado no Cell Metab (2016)

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Por Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Israelsen, William J., Bhutkar, Arjun, Clish, Clary B., Davidson, Shawn M., Luengo, Alba, Bronson, Roderick T., Jacks, Tyler, Vander Heiden, Matthew G.
Publicado no Genes Dev (2016)

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Por Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Heiden, Matthew G. Vander, Bar-Sagi, Dafna
Publicado em 2013

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Por Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
Publicado no Cell (2016)

Tissue-of-origin Dictates Branched-Chain Amino Acid Metabolism in Mutant Kras-driven Cancers

Por Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Ji, Brian W., Dixit, Purushottam D., Hosios, Aaron M., Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler, Wolpin, Brian M., Vitkup, Dennis, Vander Heiden, Matthew G.
Publicado no Science (2016)

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Por Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Publicado no eLife (2017)

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism

Por Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Davidson, Shawn M., Wirth, Gregory J., Fiske, Brian, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfredo, Patnaik, Akash, Jose Blouin, Marie, Cantley, Lewis C., Guarente, Leonard, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Publicado em 2013

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Por Grassian, Alexandra R., Parker, Seth J., Davidson, Shawn M., Divakarun, Ajit S., Green, Courtney R., Zhang, Xiamei, Slocum, Kelly L., Pu, Minying, Lin, Fallon, Vickers, Chad, Joud-Caldwell, Carol, Chung, Franklin, Yin, Hong, Handly, Erika D., Straub, Christopher, Growney, Joseph D., Vander Heiden, Matthew G., Murphy, Anne N., Pagliarini, Raymond, Metallo, Christian M.
Publicado no Cancer Res (2014)

Direct evidence for cancer cell-autonomous extracellular protein catabolism in pancreatic tumors

Por Davidson, Shawn M., Jonas, Oliver, Keibler, Mark A., Hou, Han Wei, Luengo, Alba, Mayers, Jared R., Wyckoff, Jeffrey, Del Rosario, Amanda, Whitman, Matthew, Chin, Christopher R., Condon, Kendall J., Lammers, Alex, Kellersberger, Katherine A., Stall, Brian J., Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D., Cima, Michael, Langer, Robert, Vander Heiden, Matthew G.
Publicado no Nat Med (2016)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Por Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Publicado no Cell Metab (2016)

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells

Por Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A, Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.
Publicado em 2013

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

Por Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Publicado no Nat Med (2017)

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features

Por Ouyang, Qing, Nakayama, Tojo, Baytas, Ozan, Davidson, Shawn M., Yang, Chendong, Schmidt, Michael, Lizarraga, Sofia B., Mishra, Sasmita, EI-Quessny, Malak, Niaz, Saima, Gul Butt, Mirrat, Imran Murtaza, Syed, Javed, Afzal, Chaudhry, Haroon Rashid, Vaughan, Dylan J., Hill, R. Sean, Partlow, Jennifer N., Yoo, Seung-Yun, Lam, Anh-Thu N., Nasir, Ramzi, Al-Saffar, Muna, Barkovich, A. James, Schwede, Matthew, Nagpal, Shailender, Rajab, Anna, DeBerardinis, Ralph J., Housman, David E., Mochida, Ganeshwaran H., Morrow, Eric M.
Publicado no Proc Natl Acad Sci U S A (2016)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

Por Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Publicado no Nat Chem Biol (2016)

Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

Por Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
Publicado em 2014

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Por Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J., Jiang, Jian-kang, Boxer, Matthew B., Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R., Metallo, Christian M., Fiske, Brian P., Courtney, Kevin D., Malstrom, Scott, Khan, Tahsin M., Kung, Charles, Skoumbourdis, Amanda P., Veith, Henrike, Southall, Noel, Walsh, Martin J., Brimacombe, Kyle R., Leister, William, Lunt, Sophia Y., Johnson, Zachary R., Yen, Katharine E., Kunii, Kaiko, Davidson, Shawn M., Christofk, Heather R., Austin, Christopher P., Inglese, James, Harris, Marian H., Asara, John M., Stephanopoulos, Gregory, Salituro, Francesco G., Jin, Shengfang, Dang, Lenny, Auld, Douglas S., Park, Hee-Won, Cantley, Lewis C., Thomas, Craig J., Vander Heiden, Matthew G.
Publicado em 2012