Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumor cell growth. Despite the...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:eLife
Main Authors: Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2017
נושאים:
Cancer Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624783/
https://ncbi.nlm.nih.gov/pubmed/28967864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28083
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