Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids

Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic subtype of lung adenocarcinoma with KEAP1/NRF2-mutations, which activate the endogenous oxidative stress response, undergo significant metabo...

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Gepubliceerd in:Cell Metab
Hoofdauteurs: LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004873/
https://ncbi.nlm.nih.gov/pubmed/31813821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.11.012
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