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Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids
Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic subtype of lung adenocarcinoma with KEAP1/NRF2-mutations, which activate the endogenous oxidative stress response, undergo significant metabo...
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| Publicado no: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7004873/ https://ncbi.nlm.nih.gov/pubmed/31813821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.11.012 |
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