Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids

Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic subtype of lung adenocarcinoma with KEAP1/NRF2-mutations, which activate the endogenous oxidative stress response, undergo significant metabo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Metab
Autores principales: LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004873/
https://ncbi.nlm.nih.gov/pubmed/31813821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.11.012
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares