Identification of potential immunotherapeutic targets in antigen presentation and costimulation networks

por Spaapen, Robbert, Blomen, Vincent, van Veelen, Peter, Jongsma, Marlieke, Janssen, Lennert, Janssen, George, Raaben, Matthijs, Brummelkamp, Thijn, Neefjes, Jacques
Publicado no J Immunother Cancer (2014)

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection

por Riblett, Amber M., Blomen, Vincent A., Jae, Lucas T., Altamura, Louis A., Doms, Robert W., Brummelkamp, Thijn R., Wojcechowskyj, Jason A.
Publicado no J Virol (2016)

Diverse viruses require the calcium transporter SPCA1 for maturation and spread

por Hoffmann, H.-Heinrich, Schneider, William M, Blomen, Vincent A, Scull, Margaret A, Hovnanian, Alain, Brummelkamp, Thijn R, Rice, Charles M
Publicado no Cell Host Microbe (2017)

Haploid genetic screens identify genetic vulnerabilities to microtubule‐targeting agents

por Gerhards, Nora M., Blomen, Vincent A., Mutlu, Merve, Nieuwenhuis, Joppe, Howald, Denise, Guyader, Charlotte, Jonkers, Jos, Brummelkamp, Thijn R., Rottenberg, Sven
Publicado no Mol Oncol (2018)

Generation of iPSCs from cultured human malignant cells

por Carette, Jan E., Pruszak, Jan, Varadarajan, Malini, Blomen, Vincent A., Gokhale, Sumita, Camargo, Fernando D., Wernig, Marius, Jaenisch, Rudolf, Brummelkamp, Thijn R.
Publicado em 2010

A haploid genetic screen identifies the G(1)/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

por Heijink, Anne Margriet, Blomen, Vincent A., Bisteau, Xavier, Degener, Fabian, Matsushita, Felipe Yu, Kaldis, Philipp, Foijer, Floris, van Vugt, Marcel A. T. M.
Publicado no Proc Natl Acad Sci U S A (2015)

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes

por Sarbanes, Stephanie L., Blomen, Vincent A., Lam, Eric, Heissel, Søren, Luna, Joseph M., Brummelkamp, Thijn R., Falck-Pedersen, Erik, Hoffmann, H.-Heinrich, Rice, Charles M.
Publicado no Proc Natl Acad Sci U S A (2021)

NRP2 and CD63 are host factors for Lujo virus cell entry

por Raaben, Matthijs, Jae, Lucas T., Herbert, Andrew S., Kuehne, Ana I., Stubbs, Sarah H., Chou, Yi-ying, Blomen, Vincent A., Kirchhausen, Tomas, Dye, John M., Brummelkamp, Thijn R., Whelan, Sean P.
Publicado no Cell Host Microbe (2017)

Global gene disruption in human cells to assign genes to phenotypes

por Carette, Jan E., Guimaraes, Carla P., Wuethrich, Irene, Blomen, Vincent A., Varadarajan, Malini, Sun, Chong, Bell, George, Yuan, Bingbing, Muellner, Markus K., Nijman, Sebastian M., Ploegh, Hidde L., Brummelkamp, Thijn R.
Publicado em 2011

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

por Luteijn, Rutger D., van Diemen, Ferdy, Blomen, Vincent A., Boer, Ingrid G. J., Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H., Drexler, Ingo, Brummelkamp, Thijn R., Lebbink, Robert Jan, Wiertz, Emmanuel J.
Publicado no J Virol (2019)

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

por Jacobson, Lee S., Lima, Heriberto, Goldberg, Michael F., Gocheva, Vasilena, Tsiperson, Vladislav, Sutterwala, Fayyaz S., Joyce, Johanna A., Gapp, Bianca V., Blomen, Vincent A., Chandran, Kartik, Brummelkamp, Thijn R., Diaz-Griffero, Felipe, Brojatsch, Jürgen
Publicado em 2013

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

por Jae, Lucas T., Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A., Velds, Arno, Kerkhoven, Ron. M., Carette, Jan E., Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W., Lefeber, Dirk J., Whelan, Sean P., van Bokhoven, Hans, Brummelkamp, Thijn R.
Publicado em 2013

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

por Winter, Georg E., Radic, Branka, Mayor-Ruiz, Cristina, Blomen, Vincent A, Trefzer, Claudia, Kandasamy, Richard K., Huber, Kilian V.M., Gridling, Manuela, Chen, Doris, Klampfl, Thorsten, Kralovics, Robert, Kubicek, Stefan, Fernandez-Capetillo, Oscar, Brummelkamp, Thijn R., Superti-Furga, Giulio
Publicado no Nat Chem Biol (2014)

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

por Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas, Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Publicado no Cell (2017)

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt‐based anti‐cancer drugs

por Planells‐Cases, Rosa, Lutter, Darius, Guyader, Charlotte, Gerhards, Nora M, Ullrich, Florian, Elger, Deborah A, Kucukosmanoglu, Asli, Xu, Guotai, Voss, Felizia K, Reincke, S Momsen, Stauber, Tobias, Blomen, Vincent A, Vis, Daniel J, Wessels, Lodewyk F, Brummelkamp, Thijn R, Borst, Piet, Rottenberg, Sven, Jentsch, Thomas J
Publicado no EMBO J (2015)

LZTR1 is a regulator of RAS ubiquitination and signaling

por Bigenzahn, Johannes W., Collu, Giovanna M., Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I., Heinz, Leonhard X., Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A., Müller, André C., Winter, Georg E., Kralovics, Robert, Brummelkamp, Thijn R., Mlodzik, Marek, Superti-Furga, Giulio
Publicado no Science (2018)

Enterovirus D68 receptor requirements unveiled by haploid genetics

por Baggen, Jim, Thibaut, Hendrik Jan, Staring, Jacqueline, Jae, Lucas T., Liu, Yue, Guo, Hongbo, Slager, Jasper J., de Bruin, Jost W., van Vliet, Arno L. W., Blomen, Vincent A., Overduin, Pieter, Sheng, Ju, de Haan, Cornelis A. M., de Vries, Erik, Meijer, Adam, Rossmann, Michael G., Brummelkamp, Thijn R., van Kuppeveld, Frank J. M.
Publicado no Proc Natl Acad Sci U S A (2016)

A reversible gene trap collection empowers haploid genetics in human cells

por Bürckstümmer, Tilmann, Banning, Carina, Hainzl, Philipp, Schobesberger, Richard, Kerzendorfer, Claudia, Pauler, Florian M, Chen, Doris, Them, Nicole, Schischlik, Fiorella, Rebsamen, Manuele, Smida, Michal, de la Cruz, Ferran Fece, Lapao, Ana, Liszt, Melissa, Eizinger, Benjamin, Guenzl, Philipp M, Blomen, Vincent A, Konopka, Tomasz, Gapp, Bianca, Parapatics, Katja, Maier, Barbara, Stöckl, Johannes, Fischl, Wolfgang, Salic, Sejla, Taba Casari, M Rita, Knapp, Sylvia, Bennett, Keiryn L, Bock, Christoph, Colinge, Jacques, Kralovics, Robert, Ammerer, Gustav, Casari, Georg, Brummelkamp, Thijn R, Superti-Furga, Giulio, Nijman, Sebastian M B
Publicado no Nat Methods (2013)