The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA...

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Pubblicato in:Cell
Autori principali: Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas, Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422210/
https://ncbi.nlm.nih.gov/pubmed/28475897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.013
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