WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation

The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...

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Vydáno v:Nat Genet
Hlavní autoři: Liu, Ning Qing, Maresca, Michela, van den Brand, Teun, Braccioli, Luca, Schijns, Marijne M.G.A., Teunissen, Hans, Bruneau, Benoit G., Nora, Elphège P., de Wit, Elzo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://ncbi.nlm.nih.gov/pubmed/33318687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4
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