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WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation
The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/ https://ncbi.nlm.nih.gov/pubmed/33318687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4 |
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