WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation

The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Liu, Ning Qing, Maresca, Michela, van den Brand, Teun, Braccioli, Luca, Schijns, Marijne M.G.A., Teunissen, Hans, Bruneau, Benoit G., Nora, Elphège P., de Wit, Elzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://ncbi.nlm.nih.gov/pubmed/33318687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4
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