WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation

The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...

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Bibliografiska uppgifter
I publikationen:Nat Genet
Huvudupphovsmän: Liu, Ning Qing, Maresca, Michela, van den Brand, Teun, Braccioli, Luca, Schijns, Marijne M.G.A., Teunissen, Hans, Bruneau, Benoit G., Nora, Elphège P., de Wit, Elzo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://ncbi.nlm.nih.gov/pubmed/33318687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4
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