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Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl
Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops1,2 and topologically associated domains (TADs3–6), which have important roles in gene regulation1,2,4,5,7 and recombination7–9. By binding to specific sequences10, CTCF defines contact points fo...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6080695/ https://ncbi.nlm.nih.gov/pubmed/28424523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22063 |
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