Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins

Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. How compartments, TADs, and loops are generated is unknown. It has been proposed that cohesin forms TADs and loops by extrud...

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Veröffentlicht in:EMBO J
Hauptverfasser: Wutz, Gordana, Várnai, Csilla, Nagasaka, Kota, Cisneros, David A, Stocsits, Roman R, Tang, Wen, Schoenfelder, Stefan, Jessberger, Gregor, Muhar, Matthias, Hossain, M Julius, Walther, Nike, Koch, Birgit, Kueblbeck, Moritz, Ellenberg, Jan, Zuber, Johannes, Fraser, Peter, Peters, Jan‐Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730888/
https://ncbi.nlm.nih.gov/pubmed/29217591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798004
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