ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin residence time to minutes, it has been reported tha...

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Veröffentlicht in:eLife
Hauptverfasser: Wutz, Gordana, Ladurner, Rene, St Hilaire, Brian Glenn, Stocsits, Roman R, Nagasaka, Kota, Pignard, Benoit, Sanborn, Adrian, Tang, Wen, Várnai, Csilla, Ivanov, Miroslav P, Schoenfelder, Stefan, van der Lelij, Petra, Huang, Xingfan, Dürnberger, Gerhard, Roitinger, Elisabeth, Mechtler, Karl, Davidson, Iain Finley, Fraser, Peter, Lieberman-Aiden, Erez, Peters, Jan-Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054000/
https://ncbi.nlm.nih.gov/pubmed/32065581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52091
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