Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: van der Lelij, Petra, Lieb, Simone, Jude, Julian, Wutz, Gordana, Santos, Catarina P, Falkenberg, Katrina, Schlattl, Andreas, Ban, Jozef, Schwentner, Raphaela, Hoffmann, Thomas, Kovar, Heinrich, Real, Francisco X, Waldman, Todd, Pearson, Mark A, Kraut, Norbert, Peters, Jan-Michael, Zuber, Johannes, Petronczki, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531830/
https://ncbi.nlm.nih.gov/pubmed/28691904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26980
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