Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma

The protein kinase V-Raf murine sarcoma viral oncogene homolog B (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BRAF (BRAFi) have shown high response rates and extended survival in melanoma patients bearing tumors that express BRAF Val600 mutations, but a vast majori...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Shen, Che-Hung, Kim, Sun Hye, Trousil, Sebastian, Frederick, Dennie T., Piris, Adriano, Yuan, Ping, Cai, Li, Gu, Lei, Li, Man, Lee, Jung Hyun, Mitra, Devarati, Fisher, David E., Sullivan, Ryan J., Flaherty, Keith T., Zheng, Bin
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014622/
https://ncbi.nlm.nih.gov/pubmed/27500726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4155
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