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Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma
The protein kinase V-Raf murine sarcoma viral oncogene homolog B (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BRAF (BRAFi) have shown high response rates and extended survival in melanoma patients bearing tumors that express BRAF Val600 mutations, but a vast majori...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014622/ https://ncbi.nlm.nih.gov/pubmed/27500726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4155 |
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