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WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation

The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...

詳細記述

保存先:
書誌詳細
出版年:Nat Genet
主要な著者: Liu, Ning Qing, Maresca, Michela, van den Brand, Teun, Braccioli, Luca, Schijns, Marijne M.G.A., Teunissen, Hans, Bruneau, Benoit G., Nora, Elphège P., de Wit, Elzo
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://ncbi.nlm.nih.gov/pubmed/33318687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4
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