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WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation
The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...
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| 出版年: | Nat Genet |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610352/ https://ncbi.nlm.nih.gov/pubmed/33318687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00744-4 |
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