Synthetic lethality: General principles, utility and detection using genetic screens in human cells

gan Nijman, Sebastian M.B.
Cyhoeddwyd 2011

Comparison of genetic variants in matched samples using thesaurus annotation

gan Konopka, Tomasz, Nijman, Sebastian M.B.
Cyhoeddwyd yn Bioinformatics (2016)

A thesaurus of genetic variation for interrogation of repetitive genomic regions

gan Kerzendorfer, Claudia, Konopka, Tomasz, Nijman, Sebastian M.B.
Cyhoeddwyd yn Nucleic Acids Res (2015)

Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

gan Uras, Iris Z., List, Thomas, Nijman, Sebastian M. B.
Cyhoeddwyd 2012

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

gan Mair, Barbara, Konopka, Tomasz, Kerzendorfer, Claudia, Sleiman, Katia, Salic, Sejla, Serra, Violeta, Muellner, Markus K., Theodorou, Vasiliki, Nijman, Sebastian M. B.
Cyhoeddwyd yn PLoS Genet (2016)

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

gan Essletzbichler, Patrick, Konopka, Tomasz, Santoro, Federica, Chen, Doris, Gapp, Bianca V., Kralovics, Robert, Brummelkamp, Thijn R., Nijman, Sebastian M.B., Bürckstümmer, Tilmann
Cyhoeddwyd yn Genome Res (2014)

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

gan Perne, Andrea, Muellner, Markus K., Steinrueck, Magdalena, Craig-Mueller, Nils, Mayerhofer, Julia, Schwarzinger, Ilse, Sloane, Mathew, Uras, Iris Z., Hoermann, Gregor, Nijman, Sebastian M. B., Mayerhofer, Matthias
Cyhoeddwyd 2009

Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis

gan Hoermann, Gregor, Cerny-Reiterer, Sabine, Perné, Andrea, Klauser, Miriam, Hoetzenecker, Konrad, Klein, Katharina, Müllauer, Leonhard, Gröger, Marion, Nijman, Sebastian M.B., Klepetko, Walter, Valent, Peter, Mayerhofer, Matthias
Cyhoeddwyd 2011

A generic strategy for CRISPR-Cas9-mediated gene tagging

gan Lackner, Daniel H., Carré, Alexia, Guzzardo, Paloma M., Banning, Carina, Mangena, Ramu, Henley, Tom, Oberndorfer, Sarah, Gapp, Bianca V., Nijman, Sebastian M.B., Brummelkamp, Thijn R., Bürckstümmer, Tilmann
Cyhoeddwyd yn Nat Commun (2015)

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

gan Hoshida, Yujin, Nijman, Sebastian M.B., Kobayashi, Masahiro, Chan, Jennifer A., Brunet, Jean-Philippe, Chiang, Derek Y., Villanueva, Augusto, Newell, Philippa, Ikeda, Kenji, Hashimoto, Masaji, Watanabe, Goro, Gabriel, Stacey, Friedman, Scott L., Kumada, Hiromitsu, Llovet, Josep M., Golub, Todd R.
Cyhoeddwyd 2009

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

gan Smida, Michal, Fece de la Cruz, Ferran, Kerzendorfer, Claudia, Uras, Iris Z., Mair, Barbara, Mazouzi, Abdelghani, Suchankova, Tereza, Konopka, Tomasz, Katz, Amanda M., Paz, Keren, Nagy-Bojarszky, Katalin, Muellner, Markus K., Bago-Horvath, Zsuzsanna, Haura, Eric B., Loizou, Joanna I., Nijman, Sebastian M. B.
Cyhoeddwyd yn Nat Commun (2016)

Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7

gan Gerken, Philip A., Wolstenhulme, Jamie R., Tumber, Anthony, Hatch, Stephanie B., Zhang, Yijia, Müller, Susanne, Chandler, Shane A., Mair, Barbara, Li, Fengling, Nijman, Sebastian M. B., Konietzny, Rebecca, Szommer, Tamas, Yapp, Clarence, Fedorov, Oleg, Benesch, Justin L. P., Vedadi, Masoud, Kessler, Benedikt M., Kawamura, Akane, Brennan, Paul E., Smith, Martin D.
Cyhoeddwyd yn Angew Chem Int Ed Engl (2017)

A reversible gene trap collection empowers haploid genetics in human cells

gan Bürckstümmer, Tilmann, Banning, Carina, Hainzl, Philipp, Schobesberger, Richard, Kerzendorfer, Claudia, Pauler, Florian M, Chen, Doris, Them, Nicole, Schischlik, Fiorella, Rebsamen, Manuele, Smida, Michal, de la Cruz, Ferran Fece, Lapao, Ana, Liszt, Melissa, Eizinger, Benjamin, Guenzl, Philipp M, Blomen, Vincent A, Konopka, Tomasz, Gapp, Bianca, Parapatics, Katja, Maier, Barbara, Stöckl, Johannes, Fischl, Wolfgang, Salic, Sejla, Taba Casari, M Rita, Knapp, Sylvia, Bennett, Keiryn L, Bock, Christoph, Colinge, Jacques, Kralovics, Robert, Ammerer, Gustav, Casari, Georg, Brummelkamp, Thijn R, Superti-Furga, Giulio, Nijman, Sebastian M B
Cyhoeddwyd yn Nat Methods (2013)