Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis

Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironment alterations, including increased angiogenesis, osteosclerosis, and sometimes fibrosis. Little...

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Detalhes bibliográficos
Main Authors: Hoermann, Gregor, Cerny-Reiterer, Sabine, Perné, Andrea, Klauser, Miriam, Hoetzenecker, Konrad, Klein, Katharina, Müllauer, Leonhard, Gröger, Marion, Nijman, Sebastian M.B., Klepetko, Walter, Valent, Peter, Mayerhofer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081146/
https://ncbi.nlm.nih.gov/pubmed/21457934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.020
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