Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis

Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironment alterations, including increased angiogenesis, osteosclerosis, and sometimes fibrosis. Little...

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Bibliografiske detaljer
Main Authors: Hoermann, Gregor, Cerny-Reiterer, Sabine, Perné, Andrea, Klauser, Miriam, Hoetzenecker, Konrad, Klein, Katharina, Müllauer, Leonhard, Gröger, Marion, Nijman, Sebastian M.B., Klepetko, Walter, Valent, Peter, Mayerhofer, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081146/
https://ncbi.nlm.nih.gov/pubmed/21457934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.020
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