A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Vaccinia virus is a promising viral vaccine and gene delivery candidate and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-wide insertional mutagenesis approach in human haploid cells to identify host factors crucial for vaccinia virus infection....

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Luteijn, Rutger D., van Diemen, Ferdy, Blomen, Vincent A., Boer, Ingrid G. J., Manikam Sadasivam, Saravanan, van Kuppevelt, Toin H., Drexler, Ingo, Brummelkamp, Thijn R., Lebbink, Robert Jan, Wiertz, Emmanuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580964/
https://ncbi.nlm.nih.gov/pubmed/30996093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02160-18
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