A haploid genetic screen identifies the G(1)/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases. Chemical inhibitors of Wee1 are currently being tested clinically as targeted anticancer drugs. Wee1 inhibition is thought to be preferentially cytotoxic in p53-defective cancer cells. Howe...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Heijink, Anne Margriet, Blomen, Vincent A., Bisteau, Xavier, Degener, Fabian, Matsushita, Felipe Yu, Kaldis, Philipp, Foijer, Floris, van Vugt, Marcel A. T. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679052/
https://ncbi.nlm.nih.gov/pubmed/26598692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505283112
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