Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Por Frentzas, Sophia, Simoneau, Eve, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Nathan, Mark, Wotherspoon, Andrew, Gao, Zu-hua, Shi, Yu, Van den Eynden, Gert, Daley, Frances, Peckitt, Clare, Tan, Xianming, Salman, Ayat, Lazaris, Anthoula, Gazinska, Patrycja, Berg, Tracy J., Eltahir, Zak, Ritsma, Laila, Van Rheenen, Jacco, Khashper, Alla, Brown, Gina, Nystrom, Hanna, Sund, Malin, Van Laere, Steven, Loyer, Evelyne, Dirix, Luc, Cunningham, David, Metrakos, Peter, Reynolds, Andrew R.
Publicado no Nat Med (2016)

IAP antagonists induce anti-tumor immunity in multiple myeloma

Por Chesi, Marta, Mirza, Noweeda N., Garbitt, Victoria M., Sharik, Meaghen E., Dueck, Amylou C., Asmann, Yan W., Akhmetzyanova, Ilseyar, Kosiorek, Heidi E., Calcinotto, Arianna, Riggs, Daniel L., Keane, Niamh, Ahmann, Greg J., Morrison, Kevin M., Fonseca, Rafael, Lacy, Martha Q., Dingli, David, Kumar, Shaji K., Ailawadhi, Sikander, Dispenzieri, Angela, Buadi, Francis, Gertz, Morie A., Reeder, Craig B., Lin, Yi, Chanan-Khan, Asher Alban, Stewart, A. Keith, Fooksman, David, Bergsagel, P. Leif
Publicado no Nat Med (2016)

Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies

Por Wang, Gang, McCain, Megan L., Yang, Luhan, He, Aibin, Pasqualini, Francesco Silvio, Agarwal, Ashutosh, Yuan, Hongyan, Jiang, Dawei, Zhang, Donghui, Zangi, Lior, Geva, Judith, Roberts, Amy E., Ma, Qing, Ding, Jian, Chen, Jinghai, Wang, Da-zhi, Li, Kai, Wang, Jiwu, Wanders, Ronald J. A., Kulik, Wim, Vaz, Frédéric M., Laflamme, Michael A., Murry, Charles E., Chien, Kenneth R., Kelley, Richard I., Church, George M., Parker, Kevin Kit, Pu, William T.
Publicado em 2014

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Por Lourenco, Mychael V., Frozza, Rudimar L., de Freitas, Guilherme B., Zhang, Hong, Kincheski, Grasielle C., Ribeiro, Felipe C., Gonçalves, Rafaella A., Clarke, Julia R., Beckman, Danielle, Staniszewski, Agnieszka, Berman, Hanna, Guerra, Lorena A., Forny-Germano, Letícia, Meier, Shelby, Wilcock, Donna M., de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A. M., Abisambra, Jose F., Tovar-Moll, Fernanda, Mattos, Paulo, Arancio, Ottavio, Ferreira, Sergio T., De Felice, Fernanda G.
Publicado no Nat Med (2019)

Identification of a central role for complement in osteoarthritis

Por Wang, Qian, Rozelle, Andrew L., Lepus, Christin M., Scanzello, Carla R., Song, Jason J., Larsen, D. Meegan, Crish, James F., Bebek, Gurkan, Ritter, Susan Y., Lindstrom, Tamsin M., Hwang, Inyong, Wong, Heidi H., Punzi, Leonardo, Encarnacion, Angelo, Shamloo, Mehrdad, Goodman, Stuart B., Wyss-Coray, Tony, Goldring, Steven R., Banda, Nirmal K., Thurman, Joshua M., Gobezie, Reuben, Crow, Mary K., Holers, V. Michael, Lee, David M., Robinson, William H.
Publicado em 2011

Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets

Por Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyun-Kyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenin, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X. William, Tamashiro, Kellie L. K., Aja, Susan, Moran, Timothy H., Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P., Cichewicz, Robert H., Ross, Christopher A., Holtzman, David M., Krainc, Dimitri, Duan, Wenzhen
Publicado no Nat Med (2011)

Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor

Por Huang, Bihui, Faucette, Azure N, Pawlitz, Michael D, Pei, Bo, Goyert, Joshua W, Zhou, Jordan Zheng, El-Hage, Nadim G, Deng, Jie, Lin, Jason, Yao, Fayi, Dewar, Robert S, Jassal, Japnam S, Sandberg, Maxwell L, Dai, Jing, Cols, Montserrat, Shen, Cong, Polin, Lisa A, Nichols, Ronald A, Jones, Theodore B, Bluth, Martin H, Puder, Karoline S, Gonik, Bernard, Nayak, Nihar R, Puscheck, Elizabeth, Wei, Wei-Zen, Cerutti, Andrea, Colonna, Marco, Chen, Kang
Publicado no Nat Med (2016)

A genome-wide RNA interference screen reveals an essential CREB3L2/ATF5/MCL1 survival pathway in malignant glioma with therapeutic implications

Por Sheng, Zhi, Li, Li, Zhu, Lihua J., Smith, Thomas W., Demers, Andrea, Ross, Alonzo H., Moser, Richard P., Green, Michael R.
Publicado em 2010

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

Por Bartlett, Nathan W, Walton, Ross P, Edwards, Michael R, Aniscenko, Juliya, Caramori, Gaetano, Zhu, Jie, Glanville, Nicholas, Choy, Katherine J, Jourdan, Patrick, Burnet, Jerome, Tuthill, Tobias J, Pedrick, Michael S, Hurle, Michael J, Plumpton, Chris, Sharp, Nigel A, Bussell, James N, Swallow, Dallas M, Schwarze, Jurgen, Guy, Bruno, Almond, Jeffrey W, Jeffery, Peter K, Lloyd, Clare M, Papi, Alberto, Killington, Richard A, Rowlands, David J, Blair, Edward D, Clarke, Neil J, Johnston, Sebastian L
Publicado em 2008

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

Por Vizoso, Miguel, Ferreira, Humberto J, Lopez-Serra, Paula, Javier Carmona, F, Martínez-Cardús, Anna, Girotti, Maria Romina, Villanueva, Alberto, Guil, Sonia, Moutinho, Catia, Liz, Julia, Portela, Anna, Heyn, Holger, Moran, Sebastian, Vidal, August, Martinez-Iniesta, Maria, Manzano, Jose L, Fernandez-Figueras, Maria Teresa, Elez, Elena, Muñoz-Couselo, Eva, Botella-Estrada, Rafael, Berrocal, Alfonso, Pontén, Fredrik, van den Oord, Joost, Gallagher, William M, Frederick, Dennie T, Flaherty, Keith T, McDermott, Ultan, Lorigan, Paul, Marais, Richard, Esteller, Manel
Publicado no Nat Med (2015)

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

Por Rudolph, Volker, Andrié, René P, Rudolph, Tanja K, Friedrichs, Kai, Klinke, Anna, Hirsch-Hoffmann, Birgit, Schwoerer, Alexander P, Lau, Denise, Fu, XiaoMing, Klingel, Karin, Sydow, Karsten, Didié, Michael, Seniuk, Anika, von Leitner, Eike-Christin, Szoecs, Katalin, Schrickel, Jan W, Treede, Hendrik, Wenzel, Ulrich, Lewalter, Thorsten, Nickenig, Georg, Zimmermann, Wolfram-Hubertus, Meinertz, Thomas, Böger, Rainer H, Reichenspurner, Hermann, Freeman, Bruce A, Eschenhagen, Thomas, Ehmke, Heimo, Hazen, Stanley L, Willems, Stephan, Baldus, Stephan
Publicado em 2010

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Por Bolouri, Hamid, Farrar, Jason E, Triche, Timothy, Ries, Rhonda E, Lim, Emilia L, Alonzo, Todd A, Ma, Yussanne, Moore, Richard, Mungall, Andrew J, Marra, Marco A, Zhang, Jinghui, Ma, Xiaotu, Liu, Yu, Liu, Yanling, Auvil, Jaime M Guidry, Davidsen, Tanja M, Gesuwan, Patee, Hermida, Leandro C, Salhia, Bodour, Capone, Stephen, Ramsingh, Giridharan, Zwaan, Christian Michel, Noort, Sanne, Piccolo, Stephen R, Kolb, E Anders, Gamis, Alan S, Smith, Malcolm A, Gerhard, Daniela S, Meshinchi, Soheil
Publicado no Nat Med (2017)

Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1

Por Joyal, Jean-Sébastien, Sun, Ye, Gantner, Marin L., Shao, Zhuo, Evans, Lucy P., Saba, Nicholas, Fredrick, Thomas, Burnim, Samuel, Kim, Jin Sung, Patel, Gauri, Juan, Aimee M., Hurst, Christian G., Hatton, Colman J., Cui, Zhenghao, Pierce, Kerry A., Bherer, Patrick, Aguilar, Edith, Powner, Michael B., Vevis, Kristis, Boisvert, Michel, Fu, Zhongjie, Levy, Emile, Fruttiger, Marcus, Packard, Alan, Rezende, Flavio A., Maranda, Bruno, Sapieha, Przemyslaw, Chen, Jing, Friedlander, Martin, Clish, Clary B., Smith, Lois E.H.
Publicado no Nat Med (2016)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

Por Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Publicado no Nat Med (2017)

Bone Marrow Niche Trafficking of miR-126 Controls Self-Renewal of Leukemia Stem Cells in Chronic Myelogenous Leukemia

Por Zhang, Bin, Nguyen, Le Xuan Truong, Li, Ling, Zhao, Dandan, Kumar, Bijender, Wu, Herman, Lin, Allen, Pellicano, Francesca, Hopcroft, Lisa, Su, Yu-Lin, Copland, Mhairi, Holyoake, Tessa L., Kuo, Calvin J., Bhatia, Ravi, Snyder, David S., Ali, Haris, Stein, Anthony S., Brewer, Casey, Wang, Huafeng, McDonald, Tinisha, Swiderski, Piotr, Troadec, Estelle, Chen, Ching-Cheng, Dorrance, Adrienne, Pullarkat, Vinod, Yuan, Yate-Ching, Perrotti, Danilo, Carlesso, Nadia, Forman, Stephen J., Kortylewski, Marcin, Kuo, Ya-Huei, Marcucci, Guido
Publicado no Nat Med (2018)

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Por Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L., Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H., Wang, Liewei, Wild, Peter J., Garraway, Levi A., Rubin, Mark A., Barbieri, Christopher E., Wong, Kwok-Kin, Muthuswamy, Senthil K., Huang, Jiaoti, Chen, Yu, Bradner, James E., Wei, Wenyi
Publicado no Nat Med (2017)

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

Por Li, Yun R, Li, Jin, Zhao, Sihai D, Bradfield, Jonathan P, Mentch, Frank D, Maggadottir, S Melkorka, Hou, Cuiping, Abrams, Debra J, Chang, Diana, Gao, Feng, Guo, Yiran, Wei, Zhi, Connolly, John J, Cardinale, Christopher J, Bakay, Marina, Glessner, Joseph T, Li, Dong, Kao, Charlly, Thomas, Kelly A, Qiu, Haijun, Chiavacci, Rosetta M, Kim, Cecilia E, Wang, Fengxiang, Snyder, James, Richie, Marylyn D, Flatø, Berit, Førre, Øystein, Denson, Lee A, Thompson, Susan D, Becker, Mara L, Guthery, Stephen L, Latiano, Anna, Perez, Elena, Resnick, Elena, Russell, Richard K, Wilson, David C, Silverberg, Mark S, Annese, Vito, Lie, Benedicte A, Punaro, Marilynn, Dubinsky, Marla C, Monos, Dimitri S, Strisciuglio, Caterina, Staiano, Annamaria, Miele, Erasmo, Kugathasan, Subra, Ellis, Justine A, Munro, Jane E, Sullivan, Kathleen E, Wise, Carol A, Chapel, Helen, Cunningham-Rundles, Charlotte, Grant, Struan F A, Orange, Jordan S, Sleiman, Patrick M A, Behrens, Edward M, Griffiths, Anne M, Satsangi, Jack, Finkel, Terri H, Keinan, Alon, Prak, Eline T Luning, Polychronakos, Constantin, Baldassano, Robert N, Li, Hongzhe, Keating, Brendan J, Hakonarson, Hakon
Publicado no Nat Med (2015)

Impact of Pre-adapted HIV Transmission

Por Carlson, Jonathan M., Du, Victor Y., Pfeifer, Nico, Bansal, Anju, Tan, Vincent Y.F., Power, Karen, Brumme, Chanson J., Kreimer, Anat, DeZiel, Charles E., Fusi, Nicolo, Schaefer, Malinda, Brockman, Mark A., Gilmour, Jill, Price, Matt A., Kilembe, William, Haubrich, Richard, John, Mina, Mallal, Simon, Shapiro, Roger, Frater, John, Harrigan, P. Richard, Ndung’u, Thumbi, Allen, Susan, Heckerman, David, Sidney, John, Allen, Todd M., Goulder, Philip J.R., Brumme, Zabrina L., Hunter, Eric, Goepfert, Paul A.
Publicado no Nat Med (2016)

Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice

Por Cloonan, Suzanne M., Glass, Kimberly, Laucho-Contreras, Maria E., Bhashyam, Abhiram R., Cervo, Morgan, Pabón, Maria A., Konrad, Csaba, Polverino, Francesca, Siempos, Ilias I., Perez, Elizabeth, Mizumura, Kenji, Ghosh, Manik C., Parameswaran, Harikrishnan, Williams, Niamh C., Rooney, Kristen T., Chen, Zhi-Hua, Goldklang, Monica P., Yuan, Guo-Cheng, Moore, Stephen C., Demeo, Dawn L., Rouault, Tracey A., D’Armiento, Jeanine M., Schon, Eric A., Manfredi, Giovanni, Quackenbush, John, Mahmood, Ashfaq, Silverman, Edwin K., Owen, Caroline A., Choi, Augustine M.K.
Publicado no Nat Med (2016)

Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells

Por Yahagi, Tadahiro, Yakura, Naoyuki, Matsuzaki, Keiichi, Kitanaka, Susumu
Publicado em 2013