Bone Marrow Niche Trafficking of miR-126 Controls Self-Renewal of Leukemia Stem Cells in Chronic Myelogenous Leukemia

Chronic myelogenous leukemia (CML) stem cells (LSCs) are responsible for initiating and maintaining clonal hematopoiesis. These cells persist in the bone marrow (BM) despite effective inhibition of BCR-ABL kinase activity by tyrosine kinase inhibitors (TKIs). Here, we show that although miR-126 supp...

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Publicado no:Nat Med
Main Authors: Zhang, Bin, Nguyen, Le Xuan Truong, Li, Ling, Zhao, Dandan, Kumar, Bijender, Wu, Herman, Lin, Allen, Pellicano, Francesca, Hopcroft, Lisa, Su, Yu-Lin, Copland, Mhairi, Holyoake, Tessa L., Kuo, Calvin J., Bhatia, Ravi, Snyder, David S., Ali, Haris, Stein, Anthony S., Brewer, Casey, Wang, Huafeng, McDonald, Tinisha, Swiderski, Piotr, Troadec, Estelle, Chen, Ching-Cheng, Dorrance, Adrienne, Pullarkat, Vinod, Yuan, Yate-Ching, Perrotti, Danilo, Carlesso, Nadia, Forman, Stephen J., Kortylewski, Marcin, Kuo, Ya-Huei, Marcucci, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965294/
https://ncbi.nlm.nih.gov/pubmed/29505034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4499
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