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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released upon cleavage of membrane-bound precursor protein FNDC5, also expressed in the hippocampus. Here we show that F...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6327967/ https://ncbi.nlm.nih.gov/pubmed/30617325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0275-4 |
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