Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released upon cleavage of membrane-bound precursor protein FNDC5, also expressed in the hippocampus. Here we show that F...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Lourenco, Mychael V., Frozza, Rudimar L., de Freitas, Guilherme B., Zhang, Hong, Kincheski, Grasielle C., Ribeiro, Felipe C., Gonçalves, Rafaella A., Clarke, Julia R., Beckman, Danielle, Staniszewski, Agnieszka, Berman, Hanna, Guerra, Lorena A., Forny-Germano, Letícia, Meier, Shelby, Wilcock, Donna M., de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A. M., Abisambra, Jose F., Tovar-Moll, Fernanda, Mattos, Paulo, Arancio, Ottavio, Ferreira, Sergio T., De Felice, Fernanda G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327967/
https://ncbi.nlm.nih.gov/pubmed/30617325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0275-4
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