Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

Tekijä Marszalek, Joseph R., Ruiz-Lozano, Pilar, Roberts, Elizabeth, Chien, Kenneth R., Goldstein, Lawrence S. B.
Julkaistu 1999

Novel Dendritic Kinesin Sorting Identified by Different Process Targeting of Two Related Kinesins: KIF21A and KIF21B

Tekijä Marszalek, Joseph R., Weiner, Joshua A., Farlow, Samuel J., Chun, Jerold, Goldstein, Lawrence S.B.
Julkaistu 1999

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

Tekijä Chung, Injae, Serreli, Riccardo, Cross, Jason B., Di Francesco, M. Emilia, Marszalek, Joseph R., Hirst, Judy
Julkaisussa Sci Adv (2021)

Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells

Tekijä Vangapandu, Hima V., Alston, Brandon, Morse, Joshua, Ayres, Mary L., Wierda, William G., Keating, Michael J., Marszalek, Joseph R., Gandhi, Varsha
Julkaisussa Oncotarget (2018)

Pharmacodynamics and Proteomic Analysis of Acalabrutinib Therapy: Similarity of On-Target Effects to Ibrutinib and Rationale for Combination Therapy

Tekijä Patel, Viral Kumar, Lamothe, Betty, Ayres, Mary L., Gay, Jason, Cheung, Jean, Balakrishnan, Kumudha, Ivan, Cristina, Morse, Joshua, Nelson, Mark, Keating, Michael J., Wierda, William G., Marszalek, Joseph R., Gandhi, Varsha
Julkaisussa Leukemia (2017)

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

Tekijä Chattopadhyay, Chandrani, Oba, Junna, Roszik, Jason, Marszalek, Joseph R., Chen, Ken, Qi, Yuan, Eterovic, Karina, Robertson, A. Gordon, Burks, Jared K., McCannel, Tara A., Grimm, Elizabeth A., Woodman, Scott E.
Julkaisussa Invest Ophthalmol Vis Sci (2019)

Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models

Tekijä Wang, Zebin, Sun, Kaiming, Xiao, Yonghong, Feng, Bin, Mikule, Keith, Ma, XiaoYan, Feng, Ningping, Vellano, Christopher P., Federico, Lorenzo, Marszalek, Joseph R., Mills, Gordon B., Hanke, Jeffrey, Ramaswamy, Sridhar, Wang, Jing
Julkaisussa Sci Rep (2019)

Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model

Tekijä Rytelewski, Mateusz, Harutyunyan, Karine, Baran, Natalia, Mallampati, Saradhi, Zal, M. Anna, Cavazos, Antonio, Butler, Jason M., Konoplev, Sergej, El Khatib, Mirna, Plunkett, Shane, Marszalek, Joseph R., Andreeff, Michael, Zal, Tomasz, Konopleva, Marina
Julkaisussa Front Oncol (2020)

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Tekijä Cho, Byung-Sik, Zeng, Zhihong, Mu, Hong, Wang, Zhiqiang, McQueen, Teresa, Protopopova, Marina, Cortes, Jorge, Marszalek, Joseph R., Peng, Sheng-Bin, Ma, Wencai, Davis, R. Eric, Thornton, Donald E., Andreeff, Michael, Konopleva, Marina
Julkaisussa Blood (2015)

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Tekijä Naguib, Adam, Mathew, Grinu, Reczek, Colleen R., Watrud, Kaitlin, Ambrico, Alexandra, Herzka, Tali, Salas, Irene Casanova, Lee, Matthew F., El-Amine, Nour, Zheng, Wu, Di Francesco, M. Emilia, Marszalek, Joseph R., Pappin, Darryl J., Chandel, Navdeep S., Trotman, Lloyd C.
Julkaisussa Cell Rep (2018)

Generation and testing of clinical-grade exosomes for pancreatic cancer

Tekijä Mendt, Mayela, Kamerkar, Sushrut, Sugimoto, Hikaru, McAndrews, Kathleen M., Wu, Chia-Chin, Gagea, Mihai, Yang, Sujuan, Blanko, Elena V. Rodriges, Peng, Qian, Ma, Xiaoyan, Marszalek, Joseph R., Maitra, Anirban, Yee, Cassian, Rezvani, Katayoun, Shpall, Elizabeth, LeBleu, Valerie S., Kalluri, Raghu
Julkaisussa JCI Insight (2018)

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [(18)F]FAZA PET In Vivo

Tekijä Gammon, Seth T., Pisaneschi, Federica, Bandi, Madhavi L., Smith, Melinda G., Sun, Yuting, Rao, Yi, Muller, Florian, Wong, Franklin, De Groot, John, Ackroyd, Jeffrey, Mawlawi, Osama, Davies, Michael A., Vashisht Gopal, Y.N., Di Francesco, M. Emilia, Marszalek, Joseph R., Dewhirst, Mark, Piwnica-Worms, David
Julkaisussa Cells (2019)

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Tekijä Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.
Julkaisussa Cell Stem Cell (2018)

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Tekijä Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
Julkaisussa Epigenetics Chromatin (2015)

Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models

Tekijä Benito, Juliana, Ramirez, Marc, Millward, Niki Zacharias, Velez, Juliana, Harutyunyan, Karine, Lu, Hongbo, Shi, Yuexi, Matre, Polina, Jacamo, Rodrigo, Ma, Helen, Konoplev, Sergej, McQueen, Teresa, Volgin, Andrei, Protopopova, Marina, Mu, Hong, Lee, Jaehyuk, Bhattacharya, Pratip, Marszalek, Joseph R, Davis, R. Eric, Bankson, Jim, Cortes, Jorge, Hart, Charles P, Andreeff, Michael, Konopleva, Marina
Julkaisussa Clin Cancer Res (2015)

The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies

Tekijä Vangamudi, Bhavatarini, Paul, Thomas A., Shah, Parantu K., Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R., Draetta, Giulio, Jones, Philip, Palmer, Wylie S., Sharma, Shikhar, Andersen, Jannik N.
Julkaisussa Cancer Res (2015)

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

Tekijä Powell, Reid T., Redwood, Abena, Liu, Xuan, Guo, Lei, Cai, Shirong, Zhou, Xinhui, Tu, Yizheng, Zhang, Xiaomei, Qi, Yuan, Jiang, Yan, Echeverria, Gloria, Feng, Ningping, Ma, XiaoYan, Giuliani, Virginia, Marszalek, Joseph R., Heffernan, Timothy P., Vellano, Christopher P., White, Jason B., Stephan, Clifford, Davies, Peter J., Moulder, Stacy, Symmans, W. Fraser, Chang, Jeffrey T., Piwnica-Worms, Helen
Julkaisussa Sci Rep (2020)

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Tekijä Deribe, Yonathan Lissanu, Sun, Yuting, Terranova, Christopher, Khan, Fatima, Martinez-Ledesma, Juan, Gay, Jason, Gao, Guang, Mullinax, Robert A., Khor, Tin, Feng, Ningping, Lin, Yu-Hsi, Wu, Chia-Chin, Reyes, Claudia, Peng, Qian, Robinson, Frederick, Inoue, Akira, Kochat, Veena, Liu, Chang-Gong, Asara, John M., Moran, Cesar, Muller, Florian, Wang, Jing, Fang, Bingliang, Papadimitrakopoulou, Vassiliki, Wistuba, Ignacio I., Rai, Kunal, Marszalek, Joseph R., Futreal, P. Andrew
Julkaisussa Nat Med (2018)

Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state

Tekijä Echeverria, Gloria V., Ge, Zhongqi, Seth, Sahil, Zhang, Xiaomei, Jeter-Jones, Sabrina, Zhou, Xinhui, Cai, Shirong, Tu, Yizheng, McCoy, Aaron, Peoples, Michael, Sun, Yuting, Qiu, Huan, Chang, Qing, Bristow, Christopher, Carugo, Alessandro, Shao, Jiansu, Ma, Xiaoyan, Harris, Angela, Mundi, Prabhjot, Lau, Rosanna, Ramamoorthy, Vandhana, Wu, Yun, Alvarez, Mariano J., Califano, Andrea, Moulder, Stacy L., Symmans, William F., Marszalek, Joseph R., Heffernan, Timothy P., Chang, Jeffrey T., Piwnica-Worms, Helen
Julkaisussa Sci Transl Med (2019)

An Enolase Inhibitor for the Targeted Treatment of ENO1-Deleted Cancers

Tekijä Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C., Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G., Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M., Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R., DePinho, Ronald A., Muller, Florian L.
Julkaisussa Nat Metab (2020)