Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

BACKGROUND: Proteins that ‘read’ the histone code are central elements in epigenetic control and bromodomains, which bind acetyl-lysine motifs, are increasingly recognized as potential mediators of disease states. Notably, the first BET bromodomain-based therapies have entered clinical trials and th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Epigenetics Chromatin
Main Authors: Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Methodology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578755/
https://ncbi.nlm.nih.gov/pubmed/26396593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0026-4
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