Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

BACKGROUND: Proteins that ‘read’ the histone code are central elements in epigenetic control and bromodomains, which bind acetyl-lysine motifs, are increasingly recognized as potential mediators of disease states. Notably, the first BET bromodomain-based therapies have entered clinical trials and th...

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書誌詳細
出版年:Epigenetics Chromatin
主要な著者: Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2015
主題:
Methodology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578755/
https://ncbi.nlm.nih.gov/pubmed/26396593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0026-4
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