Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A

Preventing histone recognition by bromodomains emerges as an attractive therapeutic approach in cancer. Overexpression of ATAD2A in cancer cells is associated with poor prognosis making the bromodomain of ATAD2A a promising epigenetic therapeutic target. In the development of an invitro assay and id...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Poncet-Montange, Guillaume, Zhan, Yanai, Bardenhagen, Jennifer P., Petrocchi, Alessia, Leo, Elisabetta, Shi, Xi, Lee, Gilbert R., Leonard, Paul G., Geck Do, Mary K., Cardozo, Mario G., Andersen, Jannik N., Palmer, Wylie S., Jones, Philip, Ladbury, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142613/
https://ncbi.nlm.nih.gov/pubmed/25486442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140933
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