Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A

Preventing histone recognition by bromodomains emerges as an attractive therapeutic approach in cancer. Overexpression of ATAD2A in cancer cells is associated with poor prognosis making the bromodomain of ATAD2A a promising epigenetic therapeutic target. In the development of an invitro assay and id...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Biochem J
Asıl Yazarlar: Poncet-Montange, Guillaume, Zhan, Yanai, Bardenhagen, Jennifer P., Petrocchi, Alessia, Leo, Elisabetta, Shi, Xi, Lee, Gilbert R., Leonard, Paul G., Geck Do, Mary K., Cardozo, Mario G., Andersen, Jannik N., Palmer, Wylie S., Jones, Philip, Ladbury, John E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142613/
https://ncbi.nlm.nih.gov/pubmed/25486442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140933
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller