The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies

The SWI/SNF multi-subunit complex modulates chromatin structure through the activity of two mutually exclusive catalytic subunits, SMARCA2 and SMARCA4, which both contain a bromodomain and an ATPase domain. Using RNAi, cancer-specific vulnerabilities have been identified in SWI/SNF mutant tumors, in...

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Publicado no:Cancer Res
Main Authors: Vangamudi, Bhavatarini, Paul, Thomas A., Shah, Parantu K., Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R., Draetta, Giulio, Jones, Philip, Palmer, Wylie S., Sharma, Shikhar, Andersen, Jannik N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755107/
https://ncbi.nlm.nih.gov/pubmed/26139243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3798
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