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Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models

PURPOSE: to characterize the prevalence of hypoxia in the leukemic bone marrow (BM), its association with metabolic and transcriptional changes in the leukemic blasts and the utility of hypoxia activated prodrug TH-302 in leukemia models. EXPERIMENTAL DESIGN: hyperpolarized magnetic resonance spectr...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Clin Cancer Res
Main Authors: Benito, Juliana, Ramirez, Marc, Millward, Niki Zacharias, Velez, Juliana, Harutyunyan, Karine, Lu, Hongbo, Shi, Yuexi, Matre, Polina, Jacamo, Rodrigo, Ma, Helen, Konoplev, Sergej, McQueen, Teresa, Volgin, Andrei, Protopopova, Marina, Mu, Hong, Lee, Jaehyuk, Bhattacharya, Pratip, Marszalek, Joseph R, Davis, R. Eric, Bankson, Jim, Cortes, Jorge, Hart, Charles P, Andreeff, Michael, Konopleva, Marina
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818660/
https://ncbi.nlm.nih.gov/pubmed/26603259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3378
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