Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive hematopoietic disease characterized by glutamine-dependent metabolism. A novel glutaminase (GLS) inhibitor, CB-839, is currently under evaluation for treatment of hematopoietic malignancies and solid tumors. Our purpose was to measure cellular changes in...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Zacharias, Niki M, Baran, Natalia, Shanmugavelandy, Sriram S, Lee, Jaehyuk, Lujan, Juliana Velez, Dutta, Prasanta, Millward, Steven W, Cai, Tianyu, Wood, Christopher G, Piwnica-Worms, David, Konopleva, Marina, Bhattacharya, Pratip K
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080291/
https://ncbi.nlm.nih.gov/pubmed/31387889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0985
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