Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state

Eradicating triple negative breast cancer (TNBC) resistant to neoadjuvant chemotherapy (NACT) is a critical unmet clinical need. In this study, patient-derived xenograft (PDX) models of treatment-naïve TNBC and serial biopsies from TNBC patients undergoing NACT were used to elucidate mechanisms of c...

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Publicado no:Sci Transl Med
Main Authors: Echeverria, Gloria V., Ge, Zhongqi, Seth, Sahil, Zhang, Xiaomei, Jeter-Jones, Sabrina, Zhou, Xinhui, Cai, Shirong, Tu, Yizheng, McCoy, Aaron, Peoples, Michael, Sun, Yuting, Qiu, Huan, Chang, Qing, Bristow, Christopher, Carugo, Alessandro, Shao, Jiansu, Ma, Xiaoyan, Harris, Angela, Mundi, Prabhjot, Lau, Rosanna, Ramamoorthy, Vandhana, Wu, Yun, Alvarez, Mariano J., Califano, Andrea, Moulder, Stacy L., Symmans, William F., Marszalek, Joseph R., Heffernan, Timothy P., Chang, Jeffrey T., Piwnica-Worms, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541393/
https://ncbi.nlm.nih.gov/pubmed/30996079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav0936
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